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Transcriptional Mechanisms of Drug Addiction

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Air date: Wednesday, May 06, 2009, 3:00:00 PM

Description: Addiction can be viewed as a form of drug-induced neural plasticity. Given the stability of the behavioral abnormalities that characterize an addicted state, it makes sense that stable changes in gene expression are involved. Among several transcriptional mechanisms implicated in drug addiction, our laboratory has focused on two main pathways.

First, chronic exposure to cocaine or certain other drugs of abuse causes prolonged activation of the transcription factor CREB within several brain regions, and this adaptation mediates aspects of tolerance and dependence. In contrast, induction of another transcription factor, termed ?FosB, in some of the same brain regions exerts the opposite effect and contributes to sensitized responses to drug exposure. Studies are underway to explore the detailed molecular mechanisms by which CREB and FosB regulate target genes and thereby contribute to the complex state of addiction. One way to approach such molecular mechanisms of drug action in vivo is through the study of chromatin remodeling, that is, changes in the acetylation or methylation of histones that bind to certain drug-regulated gene promoters, or changes in methylation of the promoters themselves, as revealed by chromatin immunoprecipitation (ChIP).

We are utilizing ChIP to examine chromatin changes at specific candidate genes for CREB and ?FosB, as well as ChIP on chip (immunoprecipitated chromatin analyzed by gene promoter arrays) to gain a global view of target genes for these transcription factors. We are also investigating drug regulation of some of the enzymes that catalyze chromatin remodeling as additional drug targets.

These findings establish chromatin remodeling as an important regulatory mechanism underlying drug-induced neural and behavioral plasticity, and promise to reveal fundamentally new insight into how CREB and ?FosB, and several other transcription factors, contribute to addiction by regulating the expression of specific target genes.

The NIH Director’s Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

Author: Nestler, Eric J.
National Institutes of Health (U.S.)

Runtime: 00:54:30
Permanent link: http://videocast.nih.gov/launch.asp?15089

A cocaine addiction is typically not cured instantly, but managing it is the first step to a cure. Get rid of your cocaine addiction with guidance from a practicing psychiatrist in this free video on drug addiction.

Expert: Dr George Northrup
Contact: docgmd.com
Bio: Dr. George Northrup earned his medical degree at The University of South Florida in Tampa and completed his psychiatry residency at The University of North Carolina, Chapel Hill.
Filmmaker: Christopher Rokosz

Series Description: Drug addiction is a life threatening illness, but these tips can help save someone’s life. Become aware of the signs and symptoms of drug addiction with help from a practicing psychiatrist in this free video series on drug addiction.
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12 thoughts on “Transcriptional Mechanisms of Drug Addiction


    Just another idiot who says speak to someone…im hooked like many other people out there… the fuck is tellin people to talk t someone gonna do i wanna know how to STOP and STOP bein in debt fukn moron talk to people….delete this vid absolute garbage

  2. saddle back

    fuckin sucks

  3. saddle back

    i called his office and he only helps peope that are on roxys

  4. saddle back

    fucking guy is no help

  5. saddle back

    fuck , i wachedbthat video and had to go do a toot

  6. Sabina Dervisevic


  7. basslvck(aka)MATT

    sorry but very boaring

  8. ryguycoolest2

    @squirttilithurts U should be a politician with all your blank unfactual statements my friend.. Come is the best anti depressant? Really? Yeah the comedown is really good for depression.. Also u have to doped every 45 minutes .. Real convenient.. Also cocaine is known to give anxiety.. Which is comor I'd with depression. And Also I'm married to my "first love".. Wtf does that have to do with cocaine… Silly goose.

  9. ryguycoolest2

    This video made me buy an eight ball.. Dude is so borring

  10. vikas tailor

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  11. Dawid Malinowski

    3906 videos…. MOTHERFUCKER

  12. OldeFarquer

    Once again someone recommends 12-step without offering any other support group.

    Please look up the Recovery Bill of Rights, and take special note of Item 7. No one ought to be given a religious/spiritual recommendation without also offering a secular one as well.

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